Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.
Identifieur interne : 000881 ( Main/Exploration ); précédent : 000880; suivant : 000882Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.
Auteurs : J T Lear [Royaume-Uni] ; M R Migden [États-Unis] ; K D Lewis [États-Unis] ; A L S. Chang [États-Unis] ; A. Guminski [Australie] ; R. Gutzmer [Allemagne] ; L. Dirix [Belgique] ; P. Combemale [France] ; A. Stratigos [Grèce] ; R. Plummer [Royaume-Uni] ; H. Castro [Suisse] ; T. Yi [États-Unis] ; M. Mone [États-Unis] ; J. Zhou [États-Unis] ; U. Trefzer [Allemagne] ; M. Kaatz [Allemagne] ; C. Loquai [Allemagne] ; R. Kudchadkar [États-Unis] ; D. Sellami [États-Unis] ; R. Dummer [Suisse]Source :
- Journal of the European Academy of Dermatology and Venereology : JEADV [ 1468-3083 ] ; 2017.
Abstract
Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult-to-treat populations, have had limited treatment options. Sonidegib, a hedgehog pathway inhibitor (HPI), was approved in laBCC based on results from the BOLT trial.
DOI: 10.1111/jdv.14542
PubMed: 28846163
Affiliations:
- Allemagne, Australie, Belgique, France, Grèce, Royaume-Uni, Suisse, États-Unis
- Angleterre, Attique (région), Auvergne-Rhône-Alpes, Basse-Saxe, Berlin, Californie, Canton de Zurich, Colorado, Grand Manchester, Géorgie (États-Unis), New Jersey, Rhénanie-Palatinat, Rhône-Alpes, Texas
- Athènes, Berlin, Hanovre, Lyon, Manchester, Mayence, Zurich
- Université de Manchester
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Chang</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University School of Medicine, Redwood City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University School of Medicine, Redwood City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Guminski, A" sort="Guminski, A" uniqKey="Guminski A" first="A" last="Guminski">A. Guminski</name><affiliation wicri:level="1"><nlm:affiliation>Royal North Shore Hospital, St Leonards, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Royal North Shore Hospital, St Leonards, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Gutzmer, R" sort="Gutzmer, R" uniqKey="Gutzmer R" first="R" last="Gutzmer">R. Gutzmer</name><affiliation wicri:level="3"><nlm:affiliation>Medizinische Hochschule Hannover, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Hochschule Hannover, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Dirix, L" sort="Dirix, L" uniqKey="Dirix L" first="L" last="Dirix">L. Dirix</name><affiliation wicri:level="1"><nlm:affiliation>Sint-Augustinus Ziekenhuis, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Sint-Augustinus Ziekenhuis, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Combemale, P" sort="Combemale, P" uniqKey="Combemale P" first="P" last="Combemale">P. Combemale</name><affiliation wicri:level="3"><nlm:affiliation>Anti Cancer Institute, Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Anti Cancer Institute, Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Stratigos, A" sort="Stratigos, A" uniqKey="Stratigos A" first="A" last="Stratigos">A. Stratigos</name><affiliation wicri:level="3"><nlm:affiliation>Andreas Syggros Hospital, University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Andreas Syggros Hospital, University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Plummer, R" sort="Plummer, R" uniqKey="Plummer R" first="R" last="Plummer">R. Plummer</name><affiliation wicri:level="1"><nlm:affiliation>Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne</wicri:regionArea><wicri:noRegion>Newcastle upon Tyne</wicri:noRegion></affiliation></author><author><name sortKey="Castro, H" sort="Castro, H" uniqKey="Castro H" first="H" last="Castro">H. Castro</name><affiliation wicri:level="1"><nlm:affiliation>Novartis Pharma AG, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Novartis Pharma AG, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Yi, T" sort="Yi, T" uniqKey="Yi T" first="T" last="Yi">T. Yi</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Mone, M" sort="Mone, M" uniqKey="Mone M" first="M" last="Mone">M. Mone</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Zhou, J" sort="Zhou, J" uniqKey="Zhou J" first="J" last="Zhou">J. Zhou</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Trefzer, U" sort="Trefzer, U" uniqKey="Trefzer U" first="U" last="Trefzer">U. Trefzer</name><affiliation wicri:level="3"><nlm:affiliation>Dermatologikum Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Dermatologikum Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Kaatz, M" sort="Kaatz, M" uniqKey="Kaatz M" first="M" last="Kaatz">M. Kaatz</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Jena, Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Jena, Jena</wicri:regionArea><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion><wicri:noRegion>Jena</wicri:noRegion></affiliation></author><author><name sortKey="Loquai, C" sort="Loquai, C" uniqKey="Loquai C" first="C" last="Loquai">C. Loquai</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Mainz, Mainz, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Kudchadkar, R" sort="Kudchadkar, R" uniqKey="Kudchadkar R" first="R" last="Kudchadkar">R. Kudchadkar</name><affiliation wicri:level="2"><nlm:affiliation>Winship Cancer Institute of Emory University, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Winship Cancer Institute of Emory University, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Sellami, D" sort="Sellami, D" uniqKey="Sellami D" first="D" last="Sellami">D. Sellami</name><affiliation wicri:level="2"><nlm:affiliation>Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Novartis Pharmaceuticals Corporation, East Hanover, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Dummer, R" sort="Dummer, R" uniqKey="Dummer R" first="R" last="Dummer">R. Dummer</name><affiliation wicri:level="3"><nlm:affiliation>UniversitätsSpital Zürich-Skin Cancer Center, University Hospital, Zürich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>UniversitätsSpital Zürich-Skin Cancer Center, University Hospital, Zürich</wicri:regionArea><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author></analytic><series><title level="j">Journal of the European Academy of Dermatology and Venereology : JEADV</title><idno type="eISSN">1468-3083</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult-to-treat populations, have had limited treatment options. Sonidegib, a hedgehog pathway inhibitor (HPI), was approved in laBCC based on results from the BOLT trial.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Grèce</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Basse-Saxe</li><li>Berlin</li><li>Californie</li><li>Canton de Zurich</li><li>Colorado</li><li>Grand Manchester</li><li>Géorgie (États-Unis)</li><li>New Jersey</li><li>Rhénanie-Palatinat</li><li>Rhône-Alpes</li><li>Texas</li></region><settlement><li>Athènes</li><li>Berlin</li><li>Hanovre</li><li>Lyon</li><li>Manchester</li><li>Mayence</li><li>Zurich</li></settlement><orgName><li>Université de Manchester</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lear, J T" sort="Lear, J T" uniqKey="Lear J" first="J T" last="Lear">J T Lear</name></region><name sortKey="Plummer, R" sort="Plummer, R" uniqKey="Plummer R" first="R" last="Plummer">R. Plummer</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Migden, M R" sort="Migden, M R" uniqKey="Migden M" first="M R" last="Migden">M R Migden</name></region><name sortKey="Chang, A L S" sort="Chang, A L S" uniqKey="Chang A" first="A L S" last="Chang">A L S. Chang</name><name sortKey="Kudchadkar, R" sort="Kudchadkar, R" uniqKey="Kudchadkar R" first="R" last="Kudchadkar">R. Kudchadkar</name><name sortKey="Lewis, K D" sort="Lewis, K D" uniqKey="Lewis K" first="K D" last="Lewis">K D Lewis</name><name sortKey="Mone, M" sort="Mone, M" uniqKey="Mone M" first="M" last="Mone">M. Mone</name><name sortKey="Sellami, D" sort="Sellami, D" uniqKey="Sellami D" first="D" last="Sellami">D. Sellami</name><name sortKey="Yi, T" sort="Yi, T" uniqKey="Yi T" first="T" last="Yi">T. Yi</name><name sortKey="Zhou, J" sort="Zhou, J" uniqKey="Zhou J" first="J" last="Zhou">J. Zhou</name></country><country name="Australie"><noRegion><name sortKey="Guminski, A" sort="Guminski, A" uniqKey="Guminski A" first="A" last="Guminski">A. Guminski</name></noRegion></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Gutzmer, R" sort="Gutzmer, R" uniqKey="Gutzmer R" first="R" last="Gutzmer">R. Gutzmer</name></region><name sortKey="Kaatz, M" sort="Kaatz, M" uniqKey="Kaatz M" first="M" last="Kaatz">M. Kaatz</name><name sortKey="Loquai, C" sort="Loquai, C" uniqKey="Loquai C" first="C" last="Loquai">C. Loquai</name><name sortKey="Trefzer, U" sort="Trefzer, U" uniqKey="Trefzer U" first="U" last="Trefzer">U. Trefzer</name></country><country name="Belgique"><noRegion><name sortKey="Dirix, L" sort="Dirix, L" uniqKey="Dirix L" first="L" last="Dirix">L. Dirix</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Combemale, P" sort="Combemale, P" uniqKey="Combemale P" first="P" last="Combemale">P. Combemale</name></region></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Stratigos, A" sort="Stratigos, A" uniqKey="Stratigos A" first="A" last="Stratigos">A. Stratigos</name></region></country><country name="Suisse"><noRegion><name sortKey="Castro, H" sort="Castro, H" uniqKey="Castro H" first="H" last="Castro">H. Castro</name></noRegion><name sortKey="Dummer, R" sort="Dummer, R" uniqKey="Dummer R" first="R" last="Dummer">R. Dummer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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